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School Horse Tack for Sale: The smaller ringed smaller 3.5 double ringed snaffle bit finally arrived today.... These bits have been on order since March of 2021, extremely delayed shipment. Now available, these bits are currently in stock and for sale as of April 18, 2022.
(The larger 4 1/2" size OF OUR MCLOUGHLIN SNAFFLE BITS, ARE STILL ON BACK-ORDER...WE ARE CURRENTLY OUT OF THEM!)
We are offering the Ron McLoughlin stainless 4-ring snaffle bit for sale, in both a 3.5" and
a larger 4.5" snaffle ring bit.
Expertly hand crafted, these bits make for a happy & contented mouth. Good for youngster and older horses alike.
This 4 ring snaffle bit is designed for the headstall to be connected to the large ring, and the reins attach to a smaller, free floating ring. A non-pinching, non-irritating bit. One sized 5" mouth piece.
Please note: (Currently SOLD OUT of the 4 1/2" ring snaffles.....But the smaller 3.5 McLoughlin double-ring snaffle IS available.)
MAIL CHECK TO: (Or use PayPal button below) CSSSA PO Box 599 Pearce, AZ 85625
Bits are $75.00, and $10 for the shipping within the U.S. This button is for purchasing one bit.
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The main goal of this paper is to provide an overview of the data on adverse effects of proton pump inhibitor (PPI) medication, as well to explore the role of different PPIs on cardiovascular risk factors.
Aims and Scope of the Investigation It is known that the incidence of gastrointestinal (GI) adverse events, mainly gastroduodenal problems, has been on the rise recently with introduction of proton pump inhibitors (PPIs). However, to our knowledge, little is known regarding GI adverse effects in relation to PPIs use. The objective of study was to assess GI adverse effects in a population-based cohort of patients prescribed PPIs, focusing on proton pump inhibitor (PPI) medication as the drug of choice. Data were collected on the GI adverse events, selected for being associated with risk factors, in the whole cohort (n = 24,636) on proton pump inhibitor (PPIs) use (n = 2,633), including GI events reported in clinical trials or practice guidelines. Data were also collected on other health outcomes (e.g., mortality and morbidity) in both cohorts.
Materials & Methods Study Population The was drawn from clinical practice guidelines of the University Turin (Italy), with a follow-up of 2–4 years following a baseline visit. The patients were referred to general practice by the gastroenterologists of university hospital. Patients with GI symptoms related to GERD, diabetes mellitus or a family history of GI diseases were included. Data collection The study was carried out using structured interviews (interview notes, questionnaire and in-person interviews) in a private and confidential setting. The study was approved by ethical review board of the University Turin, and study investigators patients had written informed consent to participate. Statistical Analysis Descriptive statistics and categorical variables were analysed using SPSS 17.0 (SPSS, Chicago, IL, USA). Chiâ€square tests and χ2 were used to examine differences in the data. A general linear model was used to investigate the associations in relation to PPIs, age, sex, diabetes mellitus, smoking status, presence of coronary heart disease and the presence of metabolic syndrome. All analyses were performed using the "metaâ€regression" approach (SPSS, version 17.0). Data were expressed as means ± SDs, unless otherwise specified.
Discussion Overall, this study shows a significantly increased risk of gastrointestinal/GI adverse events associated with PPIs use, both in relation to other Who makes generic effexor xr major risk factors (diabetes mellitus, dyslipidaemia and obesity) GI disorders. In particular, the risk for GI adverse events was higher in women, those with diabetes mellitus and in patients with GERD or the metabolic syndrome. A potential explanation for these findings is the presence of PPIs in general population and the risk of GI complications resulting from PPIs use, which has recently been associated with an upsurge in adverse events [23]. Proton pump inhibitors (PPIs) are considered to be among the most effective treatment options for the common GERD syndrome. use of PPIs significantly reduces dyspepsia and improves GI symptoms in patients with GERD and the metabolic syndrome. However, clinical effectiveness of PPIs in the treatment GERD is controversial, and there are also concerns about potential adverse events and side effects of PPIs. For instance, although the drug reduces symptoms of dyspepsia and improves GERD, the drug is associated with gastrointestinal complications, including diarrhea, GI bleeding, gastric ulcers and even death due to GI infections [24,25]. In fact, recent reviews on this topic suggest that the use of PPIs may be associated with increased mortality and morbidity [26,27]. Moreover, there are several studies that have found no significant change in patients' quality of life after the discontinuation PPIs, or that are of insufficient size or type to confirm these results. In the case of proton pump inhibitors (PPIs), the results of studies indicate that patients' symptoms of GERD can gradually improve with time without the discontinuation of PPIs [25–28]. Thus, our findings indicate that the adverse consequences of PPIs usage become more serious and frequent as the longer duration of use. increased frequency GI adverse events with the use of PPIs has been reported since 2006, and the frequency of GI adverse events is comparable to that with proton pump inhibitors used in children [29]. The adverse effects reported here have been shown previously in the case of PPIs children [30]. The adverse effects associated with PPIs usage appear to be different and more frequent in adolescents adults. A recent study, which assessed the prevalence of adverse GI effects by using an updated version of the GI adverse events checklist developed by the manufacturer, indicated that prevalence of adverse GI effects in the general population of young adults was similar to that reported.
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